Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis

Hiroyasu Kidoya (), Fumitaka Muramatsu, Teppei Shimamura, Weizhen Jia, Takashi Satoh, Yumiko Hayashi, Hisamichi Naito, Yuya Kunisaki, Fumio Arai, Masahide Seki, Yutaka Suzuki, Tsuyoshi Osawa, Shizuo Akira and Nobuyuki Takakura ()
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Hiroyasu Kidoya: Osaka University
Fumitaka Muramatsu: Osaka University
Teppei Shimamura: Nagoya University
Weizhen Jia: Osaka University
Takashi Satoh: Osaka University
Yumiko Hayashi: Osaka University
Hisamichi Naito: Osaka University
Yuya Kunisaki: Kyushu University
Fumio Arai: Kyushu University
Masahide Seki: The University of Tokyo
Yutaka Suzuki: The University of Tokyo
Tsuyoshi Osawa: The University of Tokyo
Shizuo Akira: Osaka University
Nobuyuki Takakura: Osaka University

Nature Communications, 2019, vol. 10, issue 1, 1-16

Abstract: Abstract The balance between self-renewal and differentiation of hematopoietic stem and progenitor cells (HSPCs) maintains hematopoietic homeostasis, failure of which can lead to hematopoietic disorder. HSPC fate is controlled by signals from the bone marrow niche resulting in alteration of the stem cell transcription network. Regnase-1, a member of the CCCH zinc finger protein family possessing RNAse activity, mediates post-transcriptional regulatory activity through degradation of target mRNAs. The precise function of Regnase-1 has been explored in inflammation-related cytokine expression but its function in hematopoiesis has not been elucidated. Here, we show that Regnase-1 regulates self-renewal of HSPCs through modulating the stability of Gata2 and Tal1 mRNA. In addition, we found that dysfunction of Regnase-1 leads to the rapid onset of abnormal hematopoiesis. Thus, our data reveal that Regnase-1-mediated post-transcriptional regulation is required for HSPC maintenance and suggest that it represents a leukemia tumor suppressor.

Date: 2019
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DOI: 10.1038/s41467-019-09028-w

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