LMO7 deficiency reveals the significance of the cuticular plate for hearing function

Ting-Ting Du, James B. Dewey, Elizabeth L. Wagner, Runjia Cui, Jinho Heo, Jeong-Jin Park, Shimon P. Francis, Edward Perez-Reyes, Stacey J. Guillot, Nicholas E. Sherman, Wenhao Xu, John S Oghalai, Bechara Kachar and Jung-Bum Shin ()
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Ting-Ting Du: University of Virginia
James B. Dewey: University of Southern California
Elizabeth L. Wagner: University of Virginia
Runjia Cui: National Institute of Health
Jinho Heo: University of Virginia
Jeong-Jin Park: University of Virginia
Shimon P. Francis: University of Virginia
Edward Perez-Reyes: University of Virginia
Stacey J. Guillot: University of Virginia
Nicholas E. Sherman: University of Virginia
Wenhao Xu: University of Virginia
John S Oghalai: University of Southern California
Bechara Kachar: National Institute of Health
Jung-Bum Shin: University of Virginia

Nature Communications, 2019, vol. 10, issue 1, 1-15

Abstract: Abstract Sensory hair cells, the mechanoreceptors of the auditory and vestibular systems, harbor two specialized elaborations of the apical surface, the hair bundle and the cuticular plate. In contrast to the extensively studied mechanosensory hair bundle, the cuticular plate is not as well understood. It is believed to provide a rigid foundation for stereocilia motion, but specifics about its function, especially the significance of its integrity for long-term maintenance of hair cell mechanotransduction, are not known. We discovered that a hair cell protein called LIM only protein 7 (LMO7) is specifically localized in the cuticular plate and the cell junction. Lmo7 KO mice suffer multiple cuticular plate deficiencies, including reduced filamentous actin density and abnormal stereociliar rootlets. In addition to the cuticular plate defects, older Lmo7 KO mice develop abnormalities in inner hair cell stereocilia. Together, these defects affect cochlear tuning and sensitivity and give rise to late-onset progressive hearing loss.

Date: 2019
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DOI: 10.1038/s41467-019-09074-4

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