DNA-enabled rational design of fluorescence-Raman bimodal nanoprobes for cancer imaging and therapy

Suchetan Pal, Angana Ray, Chrysafis Andreou, Yadong Zhou, Tatini Rakshit, Marek Wlodarczyk, Masatomo Maeda, Ricardo Toledo-Crow, Naxhije Berisha, Jiang Yang, Hsiao-Ting Hsu, Anton Oseledchyk, Jagannath Mondal, Shengli Zou and Moritz F. Kircher ()
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Suchetan Pal: Memorial Sloan Kettering Cancer Center
Angana Ray: Tata Institute of Fundamental Research
Chrysafis Andreou: Memorial Sloan Kettering Cancer Center
Yadong Zhou: University of Central Florida
Tatini Rakshit: New York University
Marek Wlodarczyk: The Graduate Center of the City University of New York
Masatomo Maeda: Memorial Sloan Kettering Cancer Center
Ricardo Toledo-Crow: City University of New York
Naxhije Berisha: Memorial Sloan Kettering Cancer Center
Jiang Yang: Memorial Sloan Kettering Cancer Center
Hsiao-Ting Hsu: Memorial Sloan Kettering Cancer Center
Anton Oseledchyk: Memorial Sloan Kettering Cancer Center
Jagannath Mondal: Tata Institute of Fundamental Research
Shengli Zou: University of Central Florida
Moritz F. Kircher: Memorial Sloan Kettering Cancer Center

Nature Communications, 2019, vol. 10, issue 1, 1-13

Abstract: Abstract Recently, surface-enhanced Raman scattering nanoprobes have shown tremendous potential in oncological imaging owing to the high sensitivity and specificity of their fingerprint-like spectra. As current Raman scanners rely on a slow, point-by-point spectrum acquisition, there is an unmet need for faster imaging to cover a clinically relevant area in real-time. Herein, we report the rational design and optimization of fluorescence-Raman bimodal nanoparticles (FRNPs) that synergistically combine the specificity of Raman spectroscopy with the versatility and speed of fluorescence imaging. DNA-enabled molecular engineering allows the rational design of FRNPs with a detection limit as low as 5 × 10−15 M. FRNPs selectively accumulate in tumor tissue mouse cancer models and enable real-time fluorescence imaging for tumor detection, resection, and subsequent Raman-based verification of clean margins. Furthermore, FRNPs enable highly efficient image-guided photothermal ablation of tumors, widening the scope of the NPs into the therapeutic realm.

Date: 2019
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DOI: 10.1038/s41467-019-09173-2

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