Calcium-activated 14-3-3 proteins as a molecular switch in salt stress tolerance

Zhijia Yang, Chongwu Wang, Yuan Xue, Xiao Liu, She Chen, ChunPeng Song, Yongqing Yang () and Yan Guo ()
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Zhijia Yang: China Agricultural University
Chongwu Wang: China Agricultural University
Yuan Xue: China Agricultural University
Xiao Liu: China Agricultural University
She Chen: National Institute of Biological Sciences, Beijing
ChunPeng Song: Henan University
Yongqing Yang: China Agricultural University
Yan Guo: China Agricultural University

Nature Communications, 2019, vol. 10, issue 1, 1-12

Abstract: Abstract Calcium is a universal secondary messenger that triggers many cellular responses. However, it is unclear how a calcium signal is coordinately decoded by different calcium sensors, which in turn regulate downstream targets to fulfill a specific physiological function. Here we show that SOS2-LIKE PROTEIN KINASE5 (PKS5) can negatively regulate the Salt-Overly-Sensitive signaling pathway in Arabidopsis. PKS5 can interact with and phosphorylate SOS2 at Ser294, promote the interaction between SOS2 and 14-3-3 proteins, and repress SOS2 activity. However, salt stress promotes an interaction between 14-3-3 proteins and PKS5, repressing its kinase activity and releasing inhibition of SOS2. We provide evidence that 14-3-3 proteins bind to Ca2+, and that Ca2+ modulates 14-3-3-dependent regulation of SOS2 and PKS5 kinase activity. Our results suggest that a salt-induced calcium signal is decoded by 14-3-3 and SOS3/SCaBP8 proteins, which selectively activate/inactivate the downstream protein kinases SOS2 and PKS5 to regulate Na+ homeostasis by coordinately mediating plasma membrane Na+/H+ antiporter and H+-ATPase activity.

Date: 2019
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DOI: 10.1038/s41467-019-09181-2

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