Perinatal factors affect the gut microbiota up to four years after birth

Fiona Fouhy, Claire Watkins, Cian J. Hill, Carol-Anne O’Shea, Brid Nagle, Eugene M. Dempsey, Paul W. O’Toole, R. Paul Ross, C. Anthony Ryan and Catherine Stanton ()
Additional contact information
Fiona Fouhy: APC Microbiome Ireland
Claire Watkins: APC Microbiome Ireland
Cian J. Hill: APC Microbiome Ireland
Carol-Anne O’Shea: Cork University Maternity Hospital
Brid Nagle: Teagasc Food Research Centre, Moorepark, Fermoy, Co
Eugene M. Dempsey: Cork University Maternity Hospital
Paul W. O’Toole: APC Microbiome Ireland
R. Paul Ross: APC Microbiome Ireland
C. Anthony Ryan: APC Microbiome Ireland
Catherine Stanton: APC Microbiome Ireland

Nature Communications, 2019, vol. 10, issue 1, 1-10

Abstract: Abstract Perinatal factors impact gut microbiota development in early life, however, little is known on the effects of these factors on microbes in later life. Here we sequence DNA from faecal samples of children over the first four years and reveal a perpetual evolution of the gut microbiota during this period. The significant impact of gestational age at birth and delivery mode on gut microbiota progression is evident in the first four years of life, while no measurable effects of antibiotics are found in the first year. Microbiota profiles are also characteristic in children dependant on gestational age and maturity. Full term delivery is characterised by Bacteroides (year one), Parabacteroides (year two) and Christensenellaceae (year four). Preterm delivery is characterised by Lactobacillus (year one), Streptococcus (year two) and Carnobacterium (year four). This study reveals that the gut retains distinct microbial profiles of perinatal factors up to four years of age.

Date: 2019
References: Add references at CitEc
Citations: View citations in EconPapers (2)

Downloads: (external link)
https://www.nature.com/articles/s41467-019-09252-4 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-09252-4

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-019-09252-4

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().