Aedes mosquitoes acquire and transmit Zika virus by breeding in contaminated aquatic environments

Senyan Du, Yang Liu, Jianying Liu, Jie Zhao, Clara Champagne, Liangqin Tong, Renli Zhang, Fuchun Zhang, Cheng-Feng Qin, Ping Ma, Chun-Hong Chen, Guodong Liang, Qiyong Liu, Pei-Yong Shi, Bernard Cazelles, Penghua Wang, Huaiyu Tian () and Gong Cheng ()
Additional contact information
Senyan Du: Tsinghua University
Yang Liu: Tsinghua University
Jianying Liu: Tsinghua University
Jie Zhao: Tsinghua University
Clara Champagne: UMR 8197 CNRS-ENS Ecole Normale Supérieure
Liangqin Tong: Tsinghua University
Renli Zhang: Shenzhen Center for Disease Control and Prevention
Fuchun Zhang: Guangzhou Medical University
Cheng-Feng Qin: Beijing Institute of Microbiology and Epidemiology
Ping Ma: Tsinghua University Hospital
Chun-Hong Chen: National Health Research Institutes, Zhunan
Guodong Liang: National Institute for Viral Disease Control and Prevention, China CDC
Qiyong Liu: National Institute for Communicable Disease Control and Prevention, China CDC
Pei-Yong Shi: University of Texas Medical Branch
Bernard Cazelles: UMR 8197 CNRS-ENS Ecole Normale Supérieure
Penghua Wang: the University of Connecticut Health Center
Huaiyu Tian: Beijing Normal University
Gong Cheng: Tsinghua University

Nature Communications, 2019, vol. 10, issue 1, 1-11

Abstract: Abstract Zika virus (ZIKV) is a mosquito-borne flavivirus that predominantly circulates between humans and Aedes mosquitoes. Clinical studies have shown that Zika viruria in patients persists for an extended period, and results in infectious virions being excreted. Here, we demonstrate that Aedes mosquitoes are permissive to ZIKV infection when breeding in urine or sewage containing low concentrations of ZIKV. Mosquito larvae and pupae, including from field Aedes aegypti can acquire ZIKV from contaminated aquatic systems, resulting in ZIKV infection of adult females. Adult mosquitoes can transmit infectious virions to susceptible type I/II interferon receptor-deficient (ifnagr-/-) C57BL/6 (AG6) mice. Furthermore, ZIKV viruria from infected AG6 mice can causes mosquito infection during the aquatic life stages. Our studies suggest that infectious urine could be a natural ZIKV source, which is potentially transmissible to mosquitoes when breeding in an aquatic environment.

Date: 2019
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DOI: 10.1038/s41467-019-09256-0

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