Temporal dynamic reorganization of 3D chromatin architecture in hormone-induced breast cancer and endocrine resistance

Yufan Zhou, Diana L. Gerrard, Junbai Wang, Tian Li, Yini Yang, Andrew J. Fritz, Mahitha Rajendran, Xiaoyong Fu, Gary Stein, Rachel Schiff, Shili Lin, Seth Frietze () and Victor X. Jin ()
Additional contact information
Yufan Zhou: University of Texas Health San Antonio
Diana L. Gerrard: University of Vermont
Junbai Wang: Oslo University Hospital—Norwegian Radium Hospital
Tian Li: University of Texas Health San Antonio
Yini Yang: University of Texas Health San Antonio
Andrew J. Fritz: University of Vermont
Mahitha Rajendran: Baylor College of Medicine
Xiaoyong Fu: Baylor College of Medicine
Gary Stein: University of Vermont Larner College of Medicine
Rachel Schiff: Baylor College of Medicine
Shili Lin: The Ohio State University
Seth Frietze: University of Vermont
Victor X. Jin: University of Texas Health San Antonio

Nature Communications, 2019, vol. 10, issue 1, 1-14

Abstract: Abstract Recent studies have demonstrated that chromatin architecture is linked to the progression of cancers. However, the roles of 3D structure and its dynamics in hormone-dependent breast cancer and endocrine resistance are largely unknown. Here we report the dynamics of 3D chromatin structure across a time course of estradiol (E2) stimulation in human estrogen receptor α (ERα)-positive breast cancer cells. We identified subsets of temporally highly dynamic compartments predominantly associated with active open chromatin and found that these highly dynamic compartments showed higher alteration in tamoxifen-resistant breast cancer cells. Remarkably, these compartments are characterized by active chromatin states, and enhanced ERα binding but decreased transcription factor CCCTC-binding factor (CTCF) binding. We finally identified a set of ERα-bound promoter–enhancer looping genes enclosed within altered domains that are enriched with cancer invasion, aggressiveness or metabolism signaling pathways. This large-scale analysis expands our understanding of high-order temporal chromatin reorganization underlying hormone-dependent breast cancer.

Date: 2019
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/s41467-019-09320-9 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-09320-9

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-019-09320-9

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().