Ligand design strategies to increase stability of gadolinium-based magnetic resonance imaging contrast agents

Thomas J. Clough, Lijun Jiang, Ka-Leung Wong () and Nicholas J. Long ()
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Thomas J. Clough: Molecular Sciences Research Hub, White City Campus
Lijun Jiang: Molecular Sciences Research Hub, White City Campus
Ka-Leung Wong: Hong Kong Baptist University
Nicholas J. Long: Molecular Sciences Research Hub, White City Campus

Nature Communications, 2019, vol. 10, issue 1, 1-14

Abstract: Abstract Gadolinium(III) complexes have been widely utilised as magnetic resonance imaging (MRI) contrast agents for decades. In recent years however, concerns have developed about their toxicity, believed to derive from demetallation of the complexes in vivo, and the relatively large quantities of compound required for a successful scan. Recent efforts have sought to enhance the relaxivity of trivalent gadolinium complexes without sacrificing their stability. This review aims to examine the strategic design of ligands synthesised for this purpose, provide an overview of recent successes in gadolinium-based contrast agent development and assess the requirements for clinical translation.

Date: 2019
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DOI: 10.1038/s41467-019-09342-3

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