Whole genome sequencing of canids reveals genomic regions under selection and variants influencing morphology

Jocelyn Plassais, Jaemin Kim, Brian W. Davis, Danielle M. Karyadi, Andrew N. Hogan, Alex C. Harris, Brennan Decker, Heidi G. Parker and Elaine A. Ostrander ()
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Jocelyn Plassais: National Institutes of Health
Jaemin Kim: National Institutes of Health
Brian W. Davis: National Institutes of Health
Danielle M. Karyadi: National Institutes of Health
Andrew N. Hogan: National Institutes of Health
Alex C. Harris: National Institutes of Health
Brennan Decker: National Institutes of Health
Heidi G. Parker: National Institutes of Health
Elaine A. Ostrander: National Institutes of Health

Nature Communications, 2019, vol. 10, issue 1, 1-14

Abstract: Abstract Domestic dog breeds are characterized by an unrivaled diversity of morphologic traits and breed-associated behaviors resulting from human selective pressures. To identify the genetic underpinnings of such traits, we analyze 722 canine whole genome sequences (WGS), documenting over 91 million single nucleotide and small indels, creating a large catalog of genomic variation for a companion animal species. We undertake both selective sweep analyses and genome wide association studies (GWAS) inclusive of over 144 modern breeds, 54 wild canids and a hundred village dogs. Our results identify variants of strong impact associated with 16 phenotypes, including body weight variation which, when combined with existing data, explain greater than 90% of body size variation in dogs. We thus demonstrate that GWAS and selection scans performed with WGS are powerful complementary methods for expanding the utility of companion animal systems for the study of mammalian growth and biology.

Date: 2019
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DOI: 10.1038/s41467-019-09373-w

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