Perfluorocarbon regulates the intratumoural environment to enhance hypoxia-based agent efficacy

Wenguang Wang, Yuhao Cheng, Peng Yu, Haoran Wang, Yue Zhang, Haiheng Xu, Qingsong Ye, Ahu Yuan (), Yiqiao Hu () and Jinhui Wu ()
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Wenguang Wang: Nanjing University
Yuhao Cheng: Nanjing University
Peng Yu: Nanjing University
Haoran Wang: Nanjing University
Yue Zhang: Nanjing University
Haiheng Xu: Nanjing University
Qingsong Ye: Nanjing University
Ahu Yuan: Nanjing University
Yiqiao Hu: Nanjing University
Jinhui Wu: Nanjing University

Nature Communications, 2019, vol. 10, issue 1, 1-11

Abstract: Abstract Hypoxia-based agents (HBAs), such as anaerobic bacteria and bioreductive prodrugs, require both a permeable and hypoxic intratumoural environment to be fully effective. To solve this problem, herein, we report that perfluorocarbon nanoparticles (PNPs) can be used to create a long-lasting, penetrable and hypoxic tumour microenvironment for ensuring both the delivery and activation of subsequently administered HBAs. In addition to the increased permeability and enhanced hypoxia caused by the PNPs, the PNPs can be retained to further achieve the long-term inhibition of intratumoural O2 reperfusion while enhancing HBA accumulation for over 24 h. Therefore, perfluorocarbon materials may have great potential for reigniting clinical research on hypoxia-based drugs.

Date: 2019
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DOI: 10.1038/s41467-019-09389-2

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