A new type of DNA phosphorothioation-based antiviral system in archaea

Lei Xiong, Siyi Liu, Si Chen, Yao Xiao, Bochen Zhu, Yali Gao, Yujing Zhang, Beibei Chen, Jie Luo, Zixin Deng, Xiangdong Chen, Lianrong Wang and Shi Chen ()
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Lei Xiong: Wuhan University
Siyi Liu: Wuhan University
Si Chen: Wuhan Polytechnic University
Yao Xiao: Wuhan University
Bochen Zhu: Wuhan University
Yali Gao: Wuhan University
Yujing Zhang: Wuhan University
Beibei Chen: Wuhan University
Jie Luo: Hubei University of Medicine
Zixin Deng: Wuhan University
Xiangdong Chen: Wuhan University
Lianrong Wang: Wuhan University
Shi Chen: Wuhan University

Nature Communications, 2019, vol. 10, issue 1, 1-11

Abstract: Abstract Archaea and Bacteria have evolved different defence strategies that target virtually all steps of the viral life cycle. The diversified virion morphotypes and genome contents of archaeal viruses result in a highly complex array of archaea-virus interactions. However, our understanding of archaeal antiviral activities lags far behind our knowledges of those in bacteria. Here we report a new archaeal defence system that involves DndCDEA-specific DNA phosphorothioate (PT) modification and the PbeABCD-mediated halt of virus propagation via inhibition of DNA replication. In contrast to the breakage of invasive DNA by DndFGH in bacteria, DndCDEA-PbeABCD does not degrade or cleave viral DNA. The PbeABCD-mediated PT defence system is widespread and exhibits extensive interdomain and intradomain gene transfer events. Our results suggest that DndCDEA-PbeABCD is a new type of PT-based virus resistance system, expanding the known arsenal of defence systems as well as our understanding of host-virus interactions.

Date: 2019
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DOI: 10.1038/s41467-019-09390-9

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