Primary cilia regulate hematopoietic stem and progenitor cell specification through Notch signaling in zebrafish

Zhibin Liu, Haiqing Tu, Yunsi Kang, Yuanyuan Xue, Dongyuan Ma, Chengtian Zhao, Huiyan Li, Lu Wang () and Feng Liu ()
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Zhibin Liu: Chinese Academy of Sciences
Haiqing Tu: National Center of Biomedical Analysis
Yunsi Kang: Ocean University of China
Yuanyuan Xue: Chinese Academy of Sciences
Dongyuan Ma: Chinese Academy of Sciences
Chengtian Zhao: Ocean University of China
Huiyan Li: National Center of Biomedical Analysis
Lu Wang: Chinese Academy of Sciences
Feng Liu: Chinese Academy of Sciences

Nature Communications, 2019, vol. 10, issue 1, 1-11

Abstract: Abstract Hematopoietic stem and progenitor cells (HSPCs) are capable of producing all mature blood lineages, as well as maintaining the self-renewal ability throughout life. The hairy-like organelle, cilium, is present in most types of vertebrate cells, and plays important roles in various biological processes. However, it is unclear whether and how cilia regulate HSPC development in vertebrates. Here, we show that cilia-specific genes, involved in primary cilia formation and function, are required for HSPC development, especially in hemogenic endothelium (HE) specification in zebrafish embryos. Blocking primary cilia formation or function by genetic or chemical manipulations impairs HSPC development. Mechanistically, we uncover that primary cilia in endothelial cells transduce Notch signal to the earliest HE for proper HSPC specification during embryogenesis. Altogether, our findings reveal a pivotal role of endothelial primary cilia in HSPC development, and may shed lights into in vitro directed differentiation of HSPCs.

Date: 2019
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DOI: 10.1038/s41467-019-09403-7

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