Meta-analysis of genome-wide association studies provides insights into genetic control of tomato flavor

Jiantao Zhao, Christopher Sauvage, Jinghua Zhao, Frédérique Bitton, Guillaume Bauchet, Dan Liu, Sanwen Huang, Denise M. Tieman, Harry J. Klee and Mathilde Causse ()
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Jiantao Zhao: INRA, UR1052, Génétique et Amélioration des Fruits et Légumes, Domaine Saint Maurice
Christopher Sauvage: INRA, UR1052, Génétique et Amélioration des Fruits et Légumes, Domaine Saint Maurice
Jinghua Zhao: University of Cambridge, Addrenbrooke’s Hospital
Frédérique Bitton: INRA, UR1052, Génétique et Amélioration des Fruits et Légumes, Domaine Saint Maurice
Guillaume Bauchet: INRA, UR1052, Génétique et Amélioration des Fruits et Légumes, Domaine Saint Maurice
Dan Liu: Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences
Sanwen Huang: Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences
Denise M. Tieman: University of Florida
Harry J. Klee: University of Florida
Mathilde Causse: INRA, UR1052, Génétique et Amélioration des Fruits et Légumes, Domaine Saint Maurice

Nature Communications, 2019, vol. 10, issue 1, 1-12

Abstract: Abstract Tomato flavor has changed over the course of long-term domestication and intensive breeding. To understand the genetic control of flavor, we report the meta-analysis of genome-wide association studies (GWAS) using 775 tomato accessions and 2,316,117 SNPs from three GWAS panels. We discover 305 significant associations for the contents of sugars, acids, amino acids, and flavor-related volatiles. We demonstrate that fruit citrate and malate contents have been impacted by selection during domestication and improvement, while sugar content has undergone less stringent selection. We suggest that it may be possible to significantly increase volatiles that positively contribute to consumer preferences while reducing unpleasant volatiles, by selection of the relevant allele combinations. Our results provide genetic insights into the influence of human selection on tomato flavor and demonstrate the benefits obtained from meta-analysis.

Date: 2019
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DOI: 10.1038/s41467-019-09462-w

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