Recollection in the human hippocampal-entorhinal cell circuitry

Bernhard P. Staresina (), Thomas P. Reber, Johannes Niediek, Jan Boström, Christian E. Elger and Florian Mormann
Additional contact information
Bernhard P. Staresina: University of Birmingham
Thomas P. Reber: University of Bonn Medical Centre
Johannes Niediek: University of Bonn Medical Centre
Jan Boström: University of Bonn Medical Centre
Christian E. Elger: University of Bonn Medical Centre
Florian Mormann: University of Bonn Medical Centre

Nature Communications, 2019, vol. 10, issue 1, 1-11

Abstract: Abstract Imagine how flicking through your photo album and seeing a picture of a beach sunset brings back fond memories of a tasty cocktail you had that night. Computational models suggest that upon receiving a partial memory cue (‘beach’), neurons in the hippocampus coordinate reinstatement of associated memories (‘cocktail’) in cortical target sites. Here, using human single neuron recordings, we show that hippocampal firing rates are elevated from ~ 500–1500 ms after cue onset during successful associative retrieval. Concurrently, the retrieved target object can be decoded from population spike patterns in adjacent entorhinal cortex (EC), with hippocampal firing preceding EC spikes and predicting the fidelity of EC object reinstatement. Prior to orchestrating reinstatement, a separate population of hippocampal neurons distinguishes different scene cues (buildings vs. landscapes). These results elucidate the hippocampal-entorhinal circuit dynamics for memory recall and reconcile disparate views on the role of the hippocampus in scene processing vs. associative memory.

Date: 2019
References: Add references at CitEc
Citations: View citations in EconPapers (5)

Downloads: (external link)
https://www.nature.com/articles/s41467-019-09558-3 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-09558-3

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-019-09558-3

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().