Free radical sensors based on inner-cutting graphene field-effect transistors

Zhen Wang, Kongyang Yi, Qiuyuan Lin, Lei Yang, Xiaosong Chen, Hui Chen, Yunqi Liu and Dacheng Wei ()
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Zhen Wang: Fudan University
Kongyang Yi: Fudan University
Qiuyuan Lin: Fudan University
Lei Yang: Fudan University
Xiaosong Chen: Fudan University
Hui Chen: Fudan University
Yunqi Liu: Fudan University
Dacheng Wei: Fudan University

Nature Communications, 2019, vol. 10, issue 1, 1-10

Abstract: Abstract Due to ultra-high reactivity, direct determination of free radicals, especially hydroxyl radical (•OH) with ultra-short lifetime, by field-effect transistor (FET) sensors remains a challenge, which hampers evaluating the role that free radical plays in physiological and pathological processes. Here, we develop a •OH FET sensor with a graphene channel functionalized by metal ion indicators. At the electrolyte/graphene interface, highly reactive •OH cuts the cysteamine to release the metal ions, resulting in surface charge de-doping and a current response. By this inner-cutting strategy, the •OH is selectively detected with a concentration down to 10−9 M. Quantitative metal ion doping enables modulation of the device sensitivity and a quasi-quantitative detection of •OH generated in aqueous solution or from living cells. Owing to its high sensitivity, selectivity, real-time label-free response, capability for quasi-quantitative detection and user-friendly portable feature, it is valuable in biological research, human health, environmental monitoring, etc.

Date: 2019
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DOI: 10.1038/s41467-019-09573-4

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