Genetic studies of accelerometer-based sleep measures yield new insights into human sleep behaviour

Samuel E. Jones, Vincent T. Hees, Diego R. Mazzotti, Pedro Marques-Vidal, Séverine Sabia, Ashley Spek, Hassan S. Dashti, Jorgen Engmann, Desana Kocevska, Jessica Tyrrell, Robin N. Beaumont, Melvyn Hillsdon, Katherine S. Ruth, Marcus A. Tuke, Hanieh Yaghootkar, Seth A. Sharp, Yingjie Ji, Jamie W. Harrison, Rachel M. Freathy, Anna Murray, Annemarie I. Luik, Najaf Amin, Jacqueline M. Lane, Richa Saxena, Martin K. Rutter, Henning Tiemeier, Zoltán Kutalik, Meena Kumari, Timothy M. Frayling, Michael N. Weedon (), Philip R. Gehrman and Andrew R. Wood ()
Additional contact information
Samuel E. Jones: University of Exeter
Vincent T. Hees: Netherlands eScience Center
Diego R. Mazzotti: University of Pennsylvania
Pedro Marques-Vidal: Lausanne University Hospital
Séverine Sabia: University College London
Ashley Spek: Erasmus MC University Medical Center
Hassan S. Dashti: Massachusetts General Hospital
Jorgen Engmann: Research department of Population Science and Experimental Medicine, Centre for Translational Genomics
Desana Kocevska: Erasmus MC University Medical Center
Jessica Tyrrell: University of Exeter
Robin N. Beaumont: University of Exeter
Melvyn Hillsdon: University of Exeter
Katherine S. Ruth: University of Exeter
Marcus A. Tuke: University of Exeter
Hanieh Yaghootkar: University of Exeter
Seth A. Sharp: University of Exeter
Yingjie Ji: University of Exeter
Jamie W. Harrison: University of Exeter
Rachel M. Freathy: University of Exeter
Anna Murray: University of Exeter
Annemarie I. Luik: Erasmus MC University Medical Center
Najaf Amin: Erasmus MC University Medical Center
Jacqueline M. Lane: Massachusetts General Hospital
Richa Saxena: Massachusetts General Hospital
Martin K. Rutter: University of Manchester
Henning Tiemeier: Erasmus MC University Medical Center
Zoltán Kutalik: Lausanne University Hospital
Meena Kumari: University of Essex, Colchester
Timothy M. Frayling: University of Exeter
Michael N. Weedon: University of Exeter
Philip R. Gehrman: University of Pennsylvania
Andrew R. Wood: University of Exeter

Nature Communications, 2019, vol. 10, issue 1, 1-12

Abstract: Abstract Sleep is an essential human function but its regulation is poorly understood. Using accelerometer data from 85,670 UK Biobank participants, we perform a genome-wide association study of 8 derived sleep traits representing sleep quality, quantity and timing, and validate our findings in 5,819 individuals. We identify 47 genetic associations at P

Date: 2019
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DOI: 10.1038/s41467-019-09576-1

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