Radical-mediated C-S bond cleavage in C2 sulfonate degradation by anaerobic bacteria

Meining Xing, Yifeng Wei, Yan Zhou, Jun Zhang, Lianyun Lin, Yiling Hu, Gaoqun Hua, Ankanahalli N. Nanjaraj Urs, Dazhi Liu, Feifei Wang, Cuixia Guo, Yang Tong, Mengya Li, Yanhong Liu, Ee Lui Ang, Huimin Zhao (), Zhiguang Yuchi () and Yan Zhang ()
Additional contact information
Meining Xing: Collaborative Innovation Center of Chemical Science and Engineering, School of Pharmaceutical Science and Technology, Tianjin University
Yifeng Wei: Institute of Chemical and Engineering Sciences, Agency for Science, Technology and Research (A*STAR)
Yan Zhou: Collaborative Innovation Center of Chemical Science and Engineering, School of Pharmaceutical Science and Technology, Tianjin University
Jun Zhang: Collaborative Innovation Center of Chemical Science and Engineering, School of Pharmaceutical Science and Technology, Tianjin University
Lianyun Lin: Collaborative Innovation Center of Chemical Science and Engineering, School of Pharmaceutical Science and Technology, Tianjin University
Yiling Hu: Collaborative Innovation Center of Chemical Science and Engineering, School of Pharmaceutical Science and Technology, Tianjin University
Gaoqun Hua: Collaborative Innovation Center of Chemical Science and Engineering, School of Pharmaceutical Science and Technology, Tianjin University
Ankanahalli N. Nanjaraj Urs: Collaborative Innovation Center of Chemical Science and Engineering, School of Pharmaceutical Science and Technology, Tianjin University
Dazhi Liu: Collaborative Innovation Center of Chemical Science and Engineering, School of Pharmaceutical Science and Technology, Tianjin University
Feifei Wang: Collaborative Innovation Center of Chemical Science and Engineering, School of Pharmaceutical Science and Technology, Tianjin University
Cuixia Guo: Collaborative Innovation Center of Chemical Science and Engineering, School of Pharmaceutical Science and Technology, Tianjin University
Yang Tong: Collaborative Innovation Center of Chemical Science and Engineering, School of Pharmaceutical Science and Technology, Tianjin University
Mengya Li: Collaborative Innovation Center of Chemical Science and Engineering, School of Pharmaceutical Science and Technology, Tianjin University
Yanhong Liu: Chinese Academy of Sciences
Ee Lui Ang: Institute of Chemical and Engineering Sciences, Agency for Science, Technology and Research (A*STAR)
Huimin Zhao: Institute of Chemical and Engineering Sciences, Agency for Science, Technology and Research (A*STAR)
Zhiguang Yuchi: Collaborative Innovation Center of Chemical Science and Engineering, School of Pharmaceutical Science and Technology, Tianjin University
Yan Zhang: Collaborative Innovation Center of Chemical Science and Engineering, School of Pharmaceutical Science and Technology, Tianjin University

Nature Communications, 2019, vol. 10, issue 1, 1-11

Abstract: Abstract Bacterial degradation of organosulfonates plays an important role in sulfur recycling, and has been extensively studied. However, this process in anaerobic bacteria especially gut bacteria is little known despite of its potential significant impact on human health with the production of toxic H2S. Here, we describe the structural and biochemical characterization of an oxygen-sensitive enzyme that catalyzes the radical-mediated C-S bond cleavage of isethionate to form sulfite and acetaldehyde. We demonstrate its involvement in pathways that enables C2 sulfonates to be used as terminal electron acceptors for anaerobic respiration in sulfate- and sulfite-reducing bacteria. Furthermore, it plays a key role in converting bile salt-derived taurine into H2S in the disease-associated gut bacterium Bilophila wadsworthia. The enzymes and transporters in these anaerobic pathways expand our understanding of microbial sulfur metabolism, and help deciphering the complex web of microbial pathways involved in the transformation of sulfur compounds in the gut.

Date: 2019
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DOI: 10.1038/s41467-019-09618-8

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