Scalable dissolution-dynamic nuclear polarization with rapid transfer of a polarized solid

Karel Kouřil (), Hana Kouřilová, Samuel Bartram, Malcolm H. Levitt and Benno Meier ()
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Karel Kouřil: University of Southampton
Hana Kouřilová: University of Southampton
Samuel Bartram: University of Southampton
Malcolm H. Levitt: University of Southampton
Benno Meier: University of Southampton

Nature Communications, 2019, vol. 10, issue 1, 1-6

Abstract: Abstract In dissolution-dynamic nuclear polarization, nuclear spins are hyperpolarized at cryogenic temperatures using radicals and microwave irradiation. The hyperpolarized solid is dissolved with hot solvent and the solution is transferred to a secondary magnet where strongly enhanced magnetic resonance signals are observed. Here we present a method for transferring the hyperpolarized solid. A bullet containing the frozen, hyperpolarized sample is ejected using pressurized helium gas, and shot into a receiving structure in the secondary magnet, where the bullet is retained and the polarized solid is dissolved rapidly. The transfer takes approximately 70 ms. A solenoid, wound along the entire transfer path ensures adiabatic transfer and limits radical-induced low-field relaxation. The method is fast and scalable towards small volumes suitable for high-resolution nuclear magnetic resonance spectroscopy while maintaining high concentrations of the target molecule. Polarization levels of approximately 30% have been observed for 1-13C-labelled pyruvic acid in solution.

Date: 2019
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DOI: 10.1038/s41467-019-09726-5

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