Microfluidic multipoles theory and applications

Pierre-Alexandre Goyette, Étienne Boulais, Frédéric Normandeau, Gabriel Laberge, David Juncker and Thomas Gervais ()
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Pierre-Alexandre Goyette: École Polytechnique de Montréal
Étienne Boulais: École Polytechnique de Montréal
Frédéric Normandeau: McGill University
Gabriel Laberge: École Polytechnique de Montréal
David Juncker: McGill University
Thomas Gervais: École Polytechnique de Montréal

Nature Communications, 2019, vol. 10, issue 1, 1-10

Abstract: Abstract Microfluidic multipoles (MFMs) have been realized experimentally and hold promise for “open-space” biological and chemical surface processing. Whereas convective flow can readily be predicted using hydraulic-electrical analogies, the design of advanced microfluidic multipole is constrained by the lack of simple, accurate models to predict mass transport within them. In this work, we introduce the complete solutions to mass transport in multipolar microfluidics based on the iterative conformal mapping of 2D advection-diffusion around a simple edge into dipoles and multipolar geometries, revealing a rich landscape of transport modes. The models are validated experimentally with a library of 3D printed devices and found in excellent agreement. Following a theory-guided design approach, we further ideate and fabricate two classes of spatiotemporally reconfigurable multipolar devices that are used for processing surfaces with time-varying reagent streams, and to realize a multistep automated immunoassay. Overall, the results set the foundations for exploring, developing, and applying open-space microfluidic multipoles.

Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-09740-7

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DOI: 10.1038/s41467-019-09740-7

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