Comprehensive genomic and immunological characterization of Chinese non-small cell lung cancer patients

Xu-Chao Zhang, Jun Wang, Guo-Guang Shao, Qun Wang, Xiaotao Qu, Bo Wang, Christopher Moy, Yue Fan, Zayed Albertyn, Xiayu Huang, Jingyu Zhang, Yang Qiu, Suso Platero, Matthew V. Lorenzi, Enrique Zudaire, Jennifer Yang, Ying Cheng, Lin Xu and Yi-Long Wu ()
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Xu-Chao Zhang: Guangdong Provincial People’s Hospital and Guangdong Academy of Medical Sciences
Jun Wang: Peking University People’s Hospital
Guo-Guang Shao: 1st Hospital of Jilin University
Qun Wang: Zhongshan Hospital, Fudan University
Xiaotao Qu: Janssen R&D China
Bo Wang: Janssen R&D China
Christopher Moy: Janssen R&D
Yue Fan: Janssen R&D China
Zayed Albertyn: Novocraft Technologies
Xiayu Huang: Janssen R&D China
Jingyu Zhang: Janssen R&D China
Yang Qiu: Janssen R&D China
Suso Platero: Janssen R&D
Matthew V. Lorenzi: Janssen R&D
Enrique Zudaire: Janssen R&D
Jennifer Yang: Janssen R&D China
Ying Cheng: Jilin Provincial Cancer Hospital
Lin Xu: Cancer Institute of Jiangsu Province
Yi-Long Wu: Guangdong Provincial People’s Hospital and Guangdong Academy of Medical Sciences

Nature Communications, 2019, vol. 10, issue 1, 1-12

Abstract: Abstract Deep understanding of the genomic and immunological differences between Chinese and Western lung cancer patients is of great importance for target therapy selection and development for Chinese patients. Here we report an extensive molecular and immune profiling study of 245 Chinese patients with non-small cell lung cancer. Tumor-infiltrating lymphocyte estimated using immune cell signatures is found to be significantly higher in adenocarcinoma (ADC, 72.5%) compared with squamous cell carcinoma (SQCC, 54.4%). The correlation of genomic alterations with immune signatures reveals that low immune infiltration was associated with EGFR mutations in ADC samples, PI3K and/or WNT pathway activation in SQCC. While KRAS mutations are found to be significantly associated with T cell infiltration in ADC samples. The SQCC patients with high antigen presentation machinery and cytotoxic T cell signature scores are found to have a prolonged overall survival time.

Date: 2019
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DOI: 10.1038/s41467-019-09762-1

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