ZFP30 promotes adipogenesis through the KAP1-mediated activation of a retrotransposon-derived Pparg2 enhancer

Wanze Chen, Petra C. Schwalie, Eugenia V. Pankevich, Carine Gubelmann, Sunil K. Raghav, Riccardo Dainese, Marco Cassano, Michael Imbeault, Suk Min Jang, Julie Russeil, Tenagne Delessa, Julien Duc, Didier Trono, Christian Wolfrum and Bart Deplancke ()
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Wanze Chen: Ecole Polytechnique Fédérale de Lausanne (EPFL)
Petra C. Schwalie: Ecole Polytechnique Fédérale de Lausanne (EPFL)
Eugenia V. Pankevich: Ecole Polytechnique Fédérale de Lausanne (EPFL)
Carine Gubelmann: Ecole Polytechnique Fédérale de Lausanne (EPFL)
Sunil K. Raghav: Ecole Polytechnique Fédérale de Lausanne (EPFL)
Riccardo Dainese: Ecole Polytechnique Fédérale de Lausanne (EPFL)
Marco Cassano: Ecole Polytechnique Fédérale de Lausanne (EPFL)
Michael Imbeault: Ecole Polytechnique Fédérale de Lausanne (EPFL)
Suk Min Jang: Ecole Polytechnique Fédérale de Lausanne (EPFL)
Julie Russeil: Ecole Polytechnique Fédérale de Lausanne (EPFL)
Tenagne Delessa: Eidgenössische Technische Hochschule Zürich (ETHZ)
Julien Duc: Ecole Polytechnique Fédérale de Lausanne (EPFL)
Didier Trono: Ecole Polytechnique Fédérale de Lausanne (EPFL)
Christian Wolfrum: Eidgenössische Technische Hochschule Zürich (ETHZ)
Bart Deplancke: Ecole Polytechnique Fédérale de Lausanne (EPFL)

Nature Communications, 2019, vol. 10, issue 1, 1-16

Abstract: Abstract Krüppel-associated box zinc finger proteins (KZFPs) constitute the largest family of mammalian transcription factors, but most remain completely uncharacterized. While initially proposed to primarily repress transposable elements, recent reports have revealed that KFZPs contribute to a wide variety of other biological processes. Using murine and human in vitro and in vivo models, we demonstrate here that one poorly studied KZFP, ZFP30, promotes adipogenesis by directly targeting and activating a retrotransposon-derived Pparg2 enhancer. Through mechanistic studies, we further show that ZFP30 recruits the co-regulator KRAB-associated protein 1 (KAP1), which, surprisingly, acts as a ZFP30 co-activator in this adipogenic context. Our findings provide an understanding of both adipogenic and KZFP-KAP1 complex-mediated gene regulation, showing that the KZFP-KAP1 axis can also function in a non-repressive manner.

Date: 2019
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DOI: 10.1038/s41467-019-09803-9

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