Spatial and temporal localization of immune transcripts defines hallmarks and diversity in the tuberculosis granuloma

Berit Carow, Thomas Hauling, Xiaoyan Qian, Igor Kramnik, Mats Nilsson and Martin E. Rottenberg ()
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Berit Carow: Karolinska Institutet
Thomas Hauling: Stockholm University
Xiaoyan Qian: Stockholm University
Igor Kramnik: Boston University School of Medicine
Mats Nilsson: Stockholm University
Martin E. Rottenberg: Karolinska Institutet

Nature Communications, 2019, vol. 10, issue 1, 1-15

Abstract: Abstract Granulomas are the pathological hallmark of tuberculosis (TB) and the niche where bacilli can grow and disseminate or the immunological microenvironment in which host cells interact to prevent bacterial dissemination. Here we show 34 immune transcripts align to the morphology of lung sections from Mycobacterium tuberculosis-infected mice at cellular resolution. Colocalizing transcript networks at

Date: 2019
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DOI: 10.1038/s41467-019-09816-4

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