SIRT3 mediates hippocampal synaptic adaptations to intermittent fasting and ameliorates deficits in APP mutant mice

Yong Liu (), Aiwu Cheng, Yu-Jiao Li, Ying Yang, Yuki Kishimoto, Shi Zhang, Yue Wang, Ruiqian Wan, Sophia M. Raefsky, Daoyuan Lu, Takashi Saito, Takaomi Saido, Jian Zhu, Long-Jun Wu and Mark P. Mattson ()
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Yong Liu: National Institute on Aging Intramural Research Program
Aiwu Cheng: National Institute on Aging Intramural Research Program
Yu-Jiao Li: Mayo Clinic
Ying Yang: National Institute on Aging Intramural Research Program
Yuki Kishimoto: National Institute on Aging Intramural Research Program
Shi Zhang: National Institute on Aging Intramural Research Program
Yue Wang: National Institute on Aging Intramural Research Program
Ruiqian Wan: National Institute on Aging Intramural Research Program
Sophia M. Raefsky: National Institute on Aging Intramural Research Program
Daoyuan Lu: National Institute on Aging Intramural Research Program
Takashi Saito: RIKEN Brain Science Institute
Takaomi Saido: RIKEN Brain Science Institute
Jian Zhu: Lieber Institute for Brain Development
Long-Jun Wu: Mayo Clinic
Mark P. Mattson: National Institute on Aging Intramural Research Program

Nature Communications, 2019, vol. 10, issue 1, 1-11

Abstract: Abstract Intermittent food deprivation (fasting, IF) improves mood and cognition and protects neurons against excitotoxic degeneration in animal models of epilepsy and Alzheimer’s disease (AD). The mechanisms by which neuronal networks adapt to IF and how such adaptations impact neuropathological processes are unknown. We show that hippocampal neuronal networks adapt to IF by enhancing GABAergic tone, which is associated with reduced anxiety-like behaviors and improved hippocampus-dependent memory. These neuronal network and behavioral adaptations require the mitochondrial protein deacetylase SIRT3 as they are abolished in SIRT3-deficient mice and wild type mice in which SIRT3 is selectively depleted from hippocampal neurons. In the AppNL-G-F mouse model of AD, IF reduces neuronal network hyperexcitability and ameliorates deficits in hippocampal synaptic plasticity in a SIRT3-dependent manner. These findings demonstrate a role for a mitochondrial protein deacetylase in hippocampal neurons in behavioral and GABAergic synaptic adaptations to IF.

Date: 2019
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DOI: 10.1038/s41467-019-09897-1

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