Regeneration of severely damaged lungs using an interventional cross-circulation platform

Brandon A. Guenthart, John D. O’Neill, Jinho Kim, Dawn Queen, Scott Chicotka, Kenmond Fung, Michael Simpson, Rachel Donocoff, Michael Salna, Charles C. Marboe, Katherine Cunningham, Susan P. Halligan, Holly M. Wobma, Ahmed E. Hozain, Alexander Romanov, Gordana Vunjak-Novakovic () and Matthew Bacchetta ()
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Brandon A. Guenthart: Columbia University
John D. O’Neill: Columbia University
Jinho Kim: Columbia University
Dawn Queen: Columbia University
Scott Chicotka: Columbia University
Kenmond Fung: Columbia University
Michael Simpson: Columbia University
Rachel Donocoff: Columbia University
Michael Salna: Columbia University
Charles C. Marboe: Columbia University
Katherine Cunningham: Columbia University
Susan P. Halligan: Columbia University
Holly M. Wobma: Columbia University
Ahmed E. Hozain: Columbia University
Alexander Romanov: Columbia University
Gordana Vunjak-Novakovic: Columbia University
Matthew Bacchetta: Columbia University

Nature Communications, 2019, vol. 10, issue 1, 1-16

Abstract: Abstract The number of available donor organs limits lung transplantation, the only lifesaving therapy for the increasing population of patients with end-stage lung disease. A prevalent etiology of injury that renders lungs unacceptable for transplantation is gastric aspiration, a deleterious insult to the pulmonary epithelium. Currently, severely damaged donor lungs cannot be salvaged with existing devices or methods. Here we report the regeneration of severely damaged lungs repaired to meet transplantation criteria by utilizing an interventional cross-circulation platform in a clinically relevant swine model of gastric aspiration injury. Enabled by cross-circulation with a living swine, prolonged extracorporeal support of damaged lungs results in significant improvements in lung function, cellular regeneration, and the development of diagnostic tools for non-invasive organ evaluation and repair. We therefore propose that the use of an interventional cross-circulation platform could enable recovery of otherwise unsalvageable lungs and thus expand the donor organ pool.

Date: 2019
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DOI: 10.1038/s41467-019-09908-1

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