A high-throughput screen indicates gemcitabine and JAK inhibitors may be useful for treating pediatric AML

Christina D. Drenberg (), Anang Shelat, Jinjun Dang, Anitria Cotton, Shelley J. Orwick, Mengyu Li, Jae Yoon Jeon, Qiang Fu, Daelynn R. Buelow, Marissa Pioso, Shuiying Hu, Hiroto Inaba, Raul C. Ribeiro, Jeffrey E. Rubnitz, Tanja A. Gruber, R. Kiplin Guy and Sharyn D. Baker
Additional contact information
Christina D. Drenberg: The Ohio State University
Anang Shelat: St. Jude Children’s Research Hospital
Jinjun Dang: St. Jude Children’s Research Hospital
Anitria Cotton: St. Jude Children’s Research Hospital
Shelley J. Orwick: The Ohio State University
Mengyu Li: The Ohio State University
Jae Yoon Jeon: The Ohio State University
Qiang Fu: The Ohio State University
Daelynn R. Buelow: The Ohio State University
Marissa Pioso: The Ohio State University
Shuiying Hu: The Ohio State University
Hiroto Inaba: St. Jude Children’s Research Hospital
Raul C. Ribeiro: St. Jude Children’s Research Hospital
Jeffrey E. Rubnitz: St. Jude Children’s Research Hospital
Tanja A. Gruber: St. Jude Children’s Research Hospital
R. Kiplin Guy: University of Kentucky
Sharyn D. Baker: The Ohio State University

Nature Communications, 2019, vol. 10, issue 1, 1-16

Abstract: Abstract Improvement in survival has been achieved for children and adolescents with AML but is largely attributed to enhanced supportive care as opposed to the development of better treatment regimens. High risk subtypes continue to have poor outcomes with event free survival rates

Date: 2019
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DOI: 10.1038/s41467-019-09917-0

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