Impaired cerebellar Purkinje cell potentiation generates unstable spatial map orientation and inaccurate navigation

Julie Marie Lefort, Jean Vincent, Lucille Tallot, Frédéric Jarlier, Chris Innocentius De Zeeuw, Laure Rondi-Reig () and Christelle Rochefort
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Julie Marie Lefort: CeZaMe
Jean Vincent: CeZaMe
Lucille Tallot: CeZaMe
Frédéric Jarlier: CeZaMe
Chris Innocentius De Zeeuw: Royal Netherlands Academy of Arts and Sciences
Laure Rondi-Reig: CeZaMe
Christelle Rochefort: CeZaMe

Nature Communications, 2019, vol. 10, issue 1, 1-13

Abstract: Abstract Cerebellar activity supported by PKC-dependent long-term depression in Purkinje cells (PCs) is involved in the stabilization of self-motion based hippocampal representation, but the existence of cerebellar processes underlying integration of allocentric cues remains unclear. Using mutant-mice lacking PP2B in PCs (L7-PP2B mice) we here assess the role of PP2B-dependent PC potentiation in hippocampal representation and spatial navigation. L7-PP2B mice display higher susceptibility to spatial map instability relative to the allocentric cue and impaired allocentric as well as self-motion goal-directed navigation. These results indicate that PP2B-dependent potentiation in PCs contributes to maintain a stable hippocampal representation of a familiar environment in an allocentric reference frame as well as to support optimal trajectory toward a goal during navigation.

Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-09958-5

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DOI: 10.1038/s41467-019-09958-5

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