Innate lymphocyte-induced CXCR3B-mediated melanocyte apoptosis is a potential initiator of T-cell autoreactivity in vitiligo

Meri K. Tulic (), Elisa Cavazza, Yann Cheli, Arnaud Jacquel, Carmelo Luci, Nathalie Cardot-Leccia, Hanene Hadhiri-Bzioueche, Patricia Abbe, Maéva Gesson, Laura Sormani, Claire Regazzetti, Guillaume E. Beranger, Cedric Lereverend, Caroline Pons, Abdallah Khemis, Robert Ballotti, Corine Bertolotto, Stéphane Rocchi and Thierry Passeron ()
Additional contact information
Meri K. Tulic: Centre Méditerranéen de Médecine Moléculaire (C3M)
Elisa Cavazza: Centre Méditerranéen de Médecine Moléculaire (C3M)
Yann Cheli: Centre Méditerranéen de Médecine Moléculaire (C3M)
Arnaud Jacquel: Centre Méditerranéen de Médecine Moléculaire (C3M)
Carmelo Luci: Centre Méditerranéen de Médecine Moléculaire (C3M)
Nathalie Cardot-Leccia: Côte d’Azur University, Department of Pathology, CHU Nice
Hanene Hadhiri-Bzioueche: Centre Méditerranéen de Médecine Moléculaire (C3M)
Patricia Abbe: Centre Méditerranéen de Médecine Moléculaire (C3M)
Maéva Gesson: Imaging Facility
Laura Sormani: Centre Méditerranéen de Médecine Moléculaire (C3M)
Claire Regazzetti: Centre Méditerranéen de Médecine Moléculaire (C3M)
Guillaume E. Beranger: Centre Méditerranéen de Médecine Moléculaire (C3M)
Cedric Lereverend: Centre Méditerranéen de Médecine Moléculaire (C3M)
Caroline Pons: Centre Méditerranéen de Médecine Moléculaire (C3M)
Abdallah Khemis: Côte d’Azur University. Department of Dermatology, CHU Nice
Robert Ballotti: Centre Méditerranéen de Médecine Moléculaire (C3M)
Corine Bertolotto: Centre Méditerranéen de Médecine Moléculaire (C3M)
Stéphane Rocchi: Centre Méditerranéen de Médecine Moléculaire (C3M)
Thierry Passeron: Centre Méditerranéen de Médecine Moléculaire (C3M)

Nature Communications, 2019, vol. 10, issue 1, 1-13

Abstract: Abstract T-cells play a crucial role in progression of autoimmunity, including vitiligo, yet the initial steps triggering their activation and tissue damage remain unknown. Here we demonstrate increased presence of type-1 innate lymphoid cells (NK and ILC1)-producing interferon gamma (IFNγ) in the blood and in non-lesional skin of vitiligo patients. Melanocytes of vitiligo patients have strong basal expression of chemokine-receptor-3 (CXCR3) isoform B which is directly regulated by IFNγ. CXCR3B activation by CXCL10 at the surface of cultured human melanocytes induces their apoptosis. The remaining melanocytes, activated by the IFNγ production, express co-stimulatory markers which trigger T-cell proliferation and subsequent anti-melanocytic immunity. Inhibiting the CXCR3B activation prevents this apoptosis and the further activation of T cells. Our results emphasize the key role of CXCR3B in apoptosis of melanocytes and identify CXCR3B as a potential target to prevent and to treat vitiligo by acting at the early stages of melanocyte destruction.

Date: 2019
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-019-09963-8 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-09963-8

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-019-09963-8

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().