Skin immunisation activates an innate lymphoid cell-monocyte axis regulating CD8+ effector recruitment to mucosal tissues

Marija Zaric, Pablo D. Becker, Catherine Hervouet, Petya Kalcheva, Andor Doszpoly, Negin Blattman, Lauren A. O’ Neill, Barbara Ibarzo Yus, Clement Cocita, Sung-Yun Kwon, Andrew H. Baker, Graham M. Lord and Linda S. Klavinskis ()
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Marija Zaric: King’s College London
Pablo D. Becker: King’s College London
Catherine Hervouet: King’s College London
Petya Kalcheva: King’s College London
Andor Doszpoly: University of Edinburgh
Negin Blattman: Arizona State University
Lauren A. O’ Neill: King’s College London
Barbara Ibarzo Yus: King’s College London
Clement Cocita: King’s College London
Sung-Yun Kwon: TheraJect Inc
Andrew H. Baker: University of Edinburgh
Graham M. Lord: King’s College London
Linda S. Klavinskis: King’s College London

Nature Communications, 2019, vol. 10, issue 1, 1-14

Abstract: Abstract CD8+ T cells provide a critical defence from pathogens at mucosal epithelia including the female reproductive tract (FRT). Mucosal immunisation is considered essential to initiate this response, however this is difficult to reconcile with evidence that antigen delivered to skin can recruit protective CD8+ T cells to mucosal tissues. Here we dissect the underlying mechanism. We show that adenovirus serotype 5 (Ad5) bio-distributes at very low level to non-lymphoid tissues after skin immunisation. This drives the expansion and activation of CD3− NK1.1+ group 1 innate lymphoid cells (ILC1) within the FRT, essential for recruitment of CD8+ T-cell effectors. Interferon gamma produced by activated ILC1 is critical to licence CD11b+Ly6C+ monocyte production of CXCL9, a chemokine required to recruit skin primed CXCR3+ CD8+T-cells to the FRT. Our findings reveal a novel role for ILC1 to recruit effector CD8+ T-cells to prevent virus spread and establish immune surveillance at barrier tissues.

Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-09969-2

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DOI: 10.1038/s41467-019-09969-2

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