Enantiomer-selective magnetization of conglomerates for quantitative chiral separation

Xichong Ye, Jiaxi Cui, Bowen Li, Na Li, Rong Wang, Zijia Yan, Junyan Tan, Jie Zhang and Xinhua Wan ()
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Xichong Ye: Peking University
Jiaxi Cui: INM - Leibniz Institute for New Materials
Bowen Li: Peking University
Na Li: Peking University
Rong Wang: Peking University
Zijia Yan: Peking University
Junyan Tan: Peking University
Jie Zhang: Peking University
Xinhua Wan: Peking University

Nature Communications, 2019, vol. 10, issue 1, 1-7

Abstract: Abstract Selective crystallization represents one of the most economical and convenient methods to provide large-scale optically pure chiral compounds. Although significant development has been achieved since Pasteur’s separation of sodium ammonium tartrate in 1848, this method is still fundamentally low efficient (low transformation ratio or high labor). Herein, we describe an enantiomer-selective-magnetization strategy for quantitatively separating the crystals of conglomerates by using a kind of magnetic nano-splitters. These nano-splitters would be selectively wrapped into the S-crystals, leading to the formation of the crystals with different physical properties from that of R-crystals. As a result of efficient separation under magnetic field, high purity chiral compounds (99.2 ee% for R-crystals, 95.0 ee% for S-crystals) can be obtained in a simple one-step crystallization process with a high separation yield (95.1%). Moreover, the nano-splitters show expandability and excellent recyclability. We foresee their great potential in developing chiral separation methods used on different scales.

Date: 2019
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DOI: 10.1038/s41467-019-09997-y

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