A strongly adhesive hemostatic hydrogel for the repair of arterial and heart bleeds

Yi Hong, Feifei Zhou, Yujie Hua, Xianzhu Zhang, Chengyao Ni, Dihao Pan, Yiqing Zhang, Deming Jiang, Long Yang, Qiuning Lin, Yiwei Zou, Dongsheng Yu, David E. Arnot, Xiaohui Zou, Linyong Zhu (), Shufang Zhang () and Hongwei Ouyang ()
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Yi Hong: Zhejiang University School of Medicine
Feifei Zhou: Zhejiang University School of Medicine
Yujie Hua: East China University of Science and Technology
Xianzhu Zhang: Zhejiang University School of Medicine
Chengyao Ni: Zhejiang University School of Medicine
Dihao Pan: Zhejiang University School of Medicine
Yiqing Zhang: East China University of Science and Technology
Deming Jiang: Zhejiang University School of Medicine
Long Yang: Zhejiang University School of Medicine
Qiuning Lin: East China University of Science and Technology
Yiwei Zou: Zhejiang University School of Medicine
Dongsheng Yu: Zhejiang University School of Medicine
David E. Arnot: Zhejiang University School of Medicine
Xiaohui Zou: Zhejiang University School of Medicine
Linyong Zhu: East China University of Science and Technology
Shufang Zhang: Zhejiang University School of Medicine
Hongwei Ouyang: Zhejiang University School of Medicine

Nature Communications, 2019, vol. 10, issue 1, 1-11

Abstract: Abstract Uncontrollable bleeding is a major problem in surgical procedures and after major trauma. Existing hemostatic agents poorly control hemorrhaging from traumatic arterial and cardiac wounds because of their weak adhesion to wet and mobile tissues. Here we design a photo-reactive adhesive that mimics the extracellular matrix (ECM) composition. This biomacromolecule-based matrix hydrogel can undergo rapid gelling and fixation to adhere and seal bleeding arteries and cardiac walls after UV light irradiation. These repairs can withstand up to 290 mm Hg blood pressure, significantly higher than blood pressures in most clinical settings (systolic BP 60–160 mm Hg). Most importantly, the hydrogel can stop high-pressure bleeding from pig carotid arteries with 4~ 5 mm-long incision wounds and from pig hearts with 6 mm diameter cardiac penetration holes. Treated pigs survived after hemostatic treatments with this hydrogel, which is well-tolerated and appears to offer significant clinical advantage as a traumatic wound sealant.

Date: 2019
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DOI: 10.1038/s41467-019-10004-7

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