Reducing MSH4 copy number prevents meiotic crossovers between non-homologous chromosomes in Brassica napus

Adrián Gonzalo, Marie-Odile Lucas, Catherine Charpentier, Greta Sandmann, Andrew Lloyd and Eric Jenczewski ()
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Adrián Gonzalo: Université Paris-Saclay
Marie-Odile Lucas: Environnement et Protection des Plantes
Catherine Charpentier: Université Paris-Saclay
Greta Sandmann: Université Paris-Saclay
Andrew Lloyd: Université Paris-Saclay
Eric Jenczewski: Université Paris-Saclay

Nature Communications, 2019, vol. 10, issue 1, 1-9

Abstract: Abstract In allopolyploids, correct chromosome segregation requires suppression of non-homologous crossovers while levels of homologous crossovers are ensured. To date, no mechanism able to specifically inhibit non-homologous crossovers has been described in allopolyploids other than in bread wheat. Here, we show that reducing the number of functional copies of MSH4, an essential gene for the main crossover pathway, prevents non-homologous crossovers in allotetraploid Brassica napus. We show that non-homologous crossovers originate almost exclusively from the MSH4-dependent recombination pathway and that their numbers decrease when MSH4 returns to single copy in B. napus; by contrast, homologous crossovers remain unaffected by MSH4 duplicate loss. We also demonstrate that MSH4 systematically returns to single copy following numerous independent polyploidy events, a pattern that is probably not by chance. These results suggest that stabilization of allopolyploid meiosis can be enhanced by loss of a key meiotic recombination gene.

Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-10010-9

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DOI: 10.1038/s41467-019-10010-9

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