Albumin tailoring fluorescence and photothermal conversion effect of near-infrared-II fluorophore with aggregation-induced emission characteristics

Shuai Gao, Guoguang Wei, Sihang Zhang, Binbin Zheng, Jiaojiao Xu, Gaoxian Chen, Mingwang Li, Shaoli Song, Wei Fu, Zeyu Xiao () and Wei Lu ()
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Shuai Gao: Fudan University
Guoguang Wei: Fudan University
Sihang Zhang: Fudan University
Binbin Zheng: Fudan University
Jiaojiao Xu: Fudan University
Gaoxian Chen: Shanghai Jiao Tong University School of Medicine
Mingwang Li: Shanghai Jiao Tong University School of Medicine
Shaoli Song: Fudan University
Wei Fu: Fudan University
Zeyu Xiao: Shanghai Jiao Tong University School of Medicine
Wei Lu: Fudan University

Nature Communications, 2019, vol. 10, issue 1, 1-15

Abstract: Abstract Fluorophores with donor-acceptor-donor groups with the emission spanning the second near-infrared window (NIR-II) have recently received great attention for biomedical application. Yet, the mechanism underlying the equilibrium between fluorescence (radiative decay) and photothermal effect (non-radiative decay) of these fluorophores remains elusive. Here, we demonstrate that a lipophilic NIR-II fluorophore, BPBBT, possesses both twisted intramolecular charge transfer (TICT) and aggregation-induced emission (AIE) characteristics. Human serum albumin (HSA) binds to BPBBT, which changes the planarity of the fluorophore and restricts its intramolecular rotation. The binding results in alteration to the equilibrium between AIE and TICT state of BPBBT, tailoring its fluorescence and photothermal efficiency. Under the guidance of intraoperative NIR-II fluorescence image, the prepared HSA-bound BPBBT nanoparticles delineate primary orthotopic mouse colon tumor and metastatic lesions with dimensions as small as 0.5 mm × 0.3 mm, and offer photothermal ablation therapy with optimized timing, dosing and area of the laser irradiation.

Date: 2019
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DOI: 10.1038/s41467-019-10056-9

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