Capturing single-cell heterogeneity via data fusion improves image-based profiling

Mohammad H. Rohban (), Hamdah S. Abbasi, Shantanu Singh and Anne E. Carpenter
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Mohammad H. Rohban: Broad Institute of MIT and Harvard
Hamdah S. Abbasi: Broad Institute of MIT and Harvard
Shantanu Singh: Broad Institute of MIT and Harvard
Anne E. Carpenter: Broad Institute of MIT and Harvard

Nature Communications, 2019, vol. 10, issue 1, 1-6

Abstract: Abstract Single-cell resolution technologies warrant computational methods that capture cell heterogeneity while allowing efficient comparisons of populations. Here, we summarize cell populations by adding features’ dispersion and covariances to population averages, in the context of image-based profiling. We find that data fusion is critical for these metrics to improve results over the prior alternatives, providing at least ~20% better performance in predicting a compound’s mechanism of action (MoA) and a gene’s pathway.

Date: 2019
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DOI: 10.1038/s41467-019-10154-8

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