The viral protein corona directs viral pathogenesis and amyloid aggregation

Kariem Ezzat (), Maria Pernemalm, Sandra Pålsson, Thomas C. Roberts, Peter Järver, Aleksandra Dondalska, Burcu Bestas, Michal J. Sobkowiak, Bettina Levänen, Magnus Sköld, Elizabeth A. Thompson, Osama Saher, Otto K. Kari, Tatu Lajunen, Eva Sverremark Ekström, Caroline Nilsson, Yevheniia Ishchenko, Tarja Malm, Matthew J. A. Wood, Ultan F. Power, Sergej Masich, Anders Lindén, Johan K. Sandberg, Janne Lehtiö, Anna-Lena Spetz () and Samir EL Andaloussi
Additional contact information
Kariem Ezzat: Stockholm University
Maria Pernemalm: Science for Life Laboratory and Karolinska Institutet
Sandra Pålsson: Stockholm University
Thomas C. Roberts: University of Oxford
Peter Järver: Stockholm University
Aleksandra Dondalska: Stockholm University
Burcu Bestas: Karolinska Institutet
Michal J. Sobkowiak: Karolinska University Hospital Huddinge
Bettina Levänen: Karolinska Institutet
Magnus Sköld: Karolinska Institutet
Elizabeth A. Thompson: Karolinska Institutet
Osama Saher: Karolinska Institutet
Otto K. Kari: University of Helsinki
Tatu Lajunen: University of Helsinki
Eva Sverremark Ekström: Stockholm University
Caroline Nilsson: Karolinska Institutet and Sachs’ Children and Youth Hospital
Yevheniia Ishchenko: University of Eastern Finland
Tarja Malm: University of Eastern Finland
Matthew J. A. Wood: University of Oxford
Ultan F. Power: Queens’ University Belfast
Sergej Masich: Karolinska Institutet
Anders Lindén: Karolinska Institutet
Johan K. Sandberg: Karolinska University Hospital Huddinge
Janne Lehtiö: Science for Life Laboratory and Karolinska Institutet
Anna-Lena Spetz: Stockholm University
Samir EL Andaloussi: Karolinska Institutet

Nature Communications, 2019, vol. 10, issue 1, 1-16

Abstract: Abstract Artificial nanoparticles accumulate a protein corona layer in biological fluids, which significantly influences their bioactivity. As nanosized obligate intracellular parasites, viruses share many biophysical properties with artificial nanoparticles in extracellular environments and here we show that respiratory syncytial virus (RSV) and herpes simplex virus type 1 (HSV-1) accumulate a rich and distinctive protein corona in different biological fluids. Moreover, we show that corona pre-coating differentially affects viral infectivity and immune cell activation. In addition, we demonstrate that viruses bind amyloidogenic peptides in their corona and catalyze amyloid formation via surface-assisted heterogeneous nucleation. Importantly, we show that HSV-1 catalyzes the aggregation of the amyloid β-peptide (Aβ42), a major constituent of amyloid plaques in Alzheimer’s disease, in vitro and in animal models. Our results highlight the viral protein corona as an acquired structural layer that is critical for viral–host interactions and illustrate a mechanistic convergence between viral and amyloid pathologies.

Date: 2019
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/s41467-019-10192-2 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-10192-2

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-019-10192-2

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().