Concentration and avidity of antibodies to different circumsporozoite epitopes correlate with RTS,S/AS01E malaria vaccine efficacy

Carlota Dobaño (), Hèctor Sanz, Hermann Sorgho, David Dosoo, Maximilian Mpina, Itziar Ubillos, Ruth Aguilar, Tom Ford, Núria Díez-Padrisa, Nana Aba Williams, Aintzane Ayestaran, Ousmane Traore, Augusto J. Nhabomba, Chenjerai Jairoce, John Waitumbi, Selidji Todagbe Agnandji, Simon Kariuki, Salim Abdulla, John J. Aponte, Benjamin Mordmüller, Kwaku Poku Asante, Seth Owusu-Agyei, Halidou Tinto, Joseph J. Campo, Gemma Moncunill, Ben Gyan, Clarissa Valim and Claudia Daubenberger
Additional contact information
Carlota Dobaño: ISGlobal, Hospital Clínic - Universitat de Barcelona
Hèctor Sanz: ISGlobal, Hospital Clínic - Universitat de Barcelona
Hermann Sorgho: Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé
David Dosoo: Kintampo Health Research Centre
Maximilian Mpina: Ifakara Health Institute, Bagamoyo Research and Training Centre
Itziar Ubillos: ISGlobal, Hospital Clínic - Universitat de Barcelona
Ruth Aguilar: ISGlobal, Hospital Clínic - Universitat de Barcelona
Tom Ford: IAVI - Human Immunology Laboratory, Imperial College
Núria Díez-Padrisa: ISGlobal, Hospital Clínic - Universitat de Barcelona
Nana Aba Williams: ISGlobal, Hospital Clínic - Universitat de Barcelona
Aintzane Ayestaran: ISGlobal, Hospital Clínic - Universitat de Barcelona
Ousmane Traore: Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé
Augusto J. Nhabomba: Centro de Investigação em Saúde de Manhiça (CISM)
Chenjerai Jairoce: Centro de Investigação em Saúde de Manhiça (CISM)
John Waitumbi: Walter Reed Army Institute of Research/Kenya Medical Research Institute
Selidji Todagbe Agnandji: Centre de Recherches Médicales de Lambaréné (CERMEL)
Simon Kariuki: Kenya Medical Research Institute/Centre for Global Health
Salim Abdulla: Ifakara Health Institute, Bagamoyo Research and Training Centre
John J. Aponte: ISGlobal, Hospital Clínic - Universitat de Barcelona
Benjamin Mordmüller: University of Tübingen
Kwaku Poku Asante: Kintampo Health Research Centre
Seth Owusu-Agyei: Kintampo Health Research Centre
Halidou Tinto: Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé
Joseph J. Campo: ISGlobal, Hospital Clínic - Universitat de Barcelona
Gemma Moncunill: ISGlobal, Hospital Clínic - Universitat de Barcelona
Ben Gyan: Kintampo Health Research Centre
Clarissa Valim: Michigan State University
Claudia Daubenberger: Swiss Tropical and Public Health Institute

Nature Communications, 2019, vol. 10, issue 1, 1-13

Abstract: Abstract RTS,S/AS01E has been tested in a phase 3 malaria vaccine study with partial efficacy in African children and infants. In a cohort of 1028 subjects from one low (Bagomoyo) and two high (Nanoro, Kintampo) malaria transmission sites, we analysed IgG plasma/serum concentration and avidity to CSP (NANP-repeat and C-terminal domains) after a 3-dose vaccination against time to clinical malaria events during 12-months. Here we report that RTS,S/AS01E induces substantial increases in IgG levels from pre- to post-vaccination (p

Date: 2019
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DOI: 10.1038/s41467-019-10195-z

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