Altered respiratory virome and serum cytokine profile associated with recurrent respiratory tract infections in children

Yanpeng Li, Xuemin Fu, Jinmin Ma, Jianhui Zhang, Yihong Hu, Wei Dong, Zhenzhou Wan, Qiongfang Li, Yi-Qun Kuang, Ke Lan, Xia Jin, Jian-Hua Wang () and Chiyu Zhang ()
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Yanpeng Li: Chinese Academy of Sciences (CAS)
Xuemin Fu: Chinese Academy of Sciences
Jinmin Ma: BGI-Shenzhen
Jianhui Zhang: Chinese Academy of Sciences (CAS)
Yihong Hu: Chinese Academy of Sciences
Wei Dong: Shanghai Nanxiang Hospital, Jiading District
Zhenzhou Wan: Medical Laboratory of Taizhou Fourth People’s Hospital
Qiongfang Li: BGI-Shenzhen
Yi-Qun Kuang: Henan University
Ke Lan: Chinese Academy of Sciences
Xia Jin: Chinese Academy of Sciences
Jian-Hua Wang: Chinese Academy of Sciences
Chiyu Zhang: Chinese Academy of Sciences (CAS)

Nature Communications, 2019, vol. 10, issue 1, 1-12

Abstract: Abstract Recurrent acute respiratory tract infections (ARTIs) affect a large population, yet the specific decisive factors are largely unknown. Here we study a population of 4407 children diagnosed with ARTI, comparing respiratory virome and serum cytokine profiles associated with multiple ARTIs and single ARTI during a six-year period. The relative abundance of Propionibacterium phages is significantly elevated in multiple ARTIs compared to single ARTI group. Serum levels of TIMP-1 and PDGF-BB are markedly increased in multiple ARTIs compared to single-ARTI and non-ARTI controls, making these two cytokines potential predictors for multiple ARTIs. The presence of Propionibacterium phages is associated with higher levels of TIMP-1 and PDGF-BB. Receiver operating characteristic (ROC) curve analyses show that the combination of TIMP-1, PDGF-BB and Propionibacterium phages could be a strong predictor for multiple ARTIs. These findings indicate that respiratory microbe homeostasis and specific cytokines are associated with the onset of multiple ARTIs over time.

Date: 2019
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DOI: 10.1038/s41467-019-10294-x

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