NREM sleep in the rodent neocortex and hippocampus reflects excitable dynamics

Daniel Levenstein, György Buzsáki and John Rinzel ()
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Daniel Levenstein: New York University
György Buzsáki: New York University
John Rinzel: New York University

Nature Communications, 2019, vol. 10, issue 1, 1-12

Abstract: Abstract During non-rapid eye movement (NREM) sleep, neuronal populations in the mammalian forebrain alternate between periods of spiking and inactivity. Termed the slow oscillation in the neocortex and sharp wave-ripples in the hippocampus, these alternations are often considered separately but are both crucial for NREM functions. By directly comparing experimental observations of naturally-sleeping rats with a mean field model of an adapting, recurrent neuronal population, we find that the neocortical alternations reflect a dynamical regime in which a stable active state is interrupted by transient inactive states (slow waves) while the hippocampal alternations reflect a stable inactive state interrupted by transient active states (sharp waves). We propose that during NREM sleep in the rodent, hippocampal and neocortical populations are excitable: each in a stable state from which internal fluctuations or external perturbation can evoke the stereotyped population events that mediate NREM functions.

Date: 2019
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DOI: 10.1038/s41467-019-10327-5

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