Adipose HuR protects against diet-induced obesity and insulin resistance

Jingyuan Li, Li Gong, Shaozhuang Liu, Yujie Zhang, Chunmei Zhang, Mi Tian, Huixia Lu, Peili Bu, Jianmin Yang, Changhan Ouyang, Xiuxin Jiang, Jiliang Wu, Yun Zhang, Qing Min (), Cheng Zhang () and Wencheng Zhang ()
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Jingyuan Li: Qilu Hospital of Shandong University
Li Gong: Qilu Hospital of Shandong University
Shaozhuang Liu: Qilu Hospital of Shandong University
Yujie Zhang: Qilu Hospital of Shandong University
Chunmei Zhang: Qilu Hospital of Shandong University
Mi Tian: Qilu Hospital of Shandong University
Huixia Lu: Qilu Hospital of Shandong University
Peili Bu: Qilu Hospital of Shandong University
Jianmin Yang: Qilu Hospital of Shandong University
Changhan Ouyang: Hubei University of Science and Technology
Xiuxin Jiang: Qilu Hospital of Shandong University
Jiliang Wu: Hubei University of Science and Technology
Yun Zhang: Qilu Hospital of Shandong University
Qing Min: Hubei University of Science and Technology
Cheng Zhang: Qilu Hospital of Shandong University
Wencheng Zhang: Qilu Hospital of Shandong University

Nature Communications, 2019, vol. 10, issue 1, 1-12

Abstract: Abstract Human antigen R (HuR) is a member of the Hu family of RNA-binding proteins and is involved in many physiological processes. Obesity, as a worldwide healthcare problem, has attracted more and more attention. To investigate the role of adipose HuR, we generate adipose-specific HuR knockout (HuRAKO) mice. As compared with control mice, HuRAKO mice show obesity when induced with a high-fat diet, along with insulin resistance, glucose intolerance, hypercholesterolemia and increased inflammation in adipose tissue. The obesity of HuRAKO mice is attributed to adipocyte hypertrophy in white adipose tissue due to decreased expression of adipose triglyceride lipase (ATGL). HuR positively regulates ATGL expression by promoting the mRNA stability and translation of ATGL. Consistently, the expression of HuR in adipose tissue is reduced in obese humans. This study suggests that adipose HuR may be a critical regulator of ATGL expression and lipolysis and thereby controls obesity and metabolic syndrome.

Date: 2019
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DOI: 10.1038/s41467-019-10348-0

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