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Vibrio sp. dhg as a platform for the biorefinery of brown macroalgae

Hyun Gyu Lim, Dong Hun Kwak, Sungwoo Park, Sunghwa Woo, Jae-Seong Yang, Chae Won Kang, Beomhee Kim, Myung Hyun Noh, Sang Woo Seo () and Gyoo Yeol Jung ()
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Hyun Gyu Lim: Pohang University of Science and Technology
Dong Hun Kwak: Pohang University of Science and Technology
Sungwoo Park: Seoul National University
Sunghwa Woo: Pohang University of Science and Technology
Jae-Seong Yang: Pohang University of Science and Technology
Chae Won Kang: Pohang University of Science and Technology
Beomhee Kim: Seoul National University
Myung Hyun Noh: Pohang University of Science and Technology
Sang Woo Seo: Seoul National University
Gyoo Yeol Jung: Pohang University of Science and Technology

Nature Communications, 2019, vol. 10, issue 1, 1-9

Abstract: Abstract Although brown macroalgae holds potential as an alternative feedstock, its utilization by conventional microbial platforms has been limited due to the inability to metabolize one of the principal sugars, alginate. Here, we isolate Vibrio sp. dhg, a fast-growing bacterium that can efficiently assimilate alginate. Based on systematic characterization of the genomic information of Vibrio sp. dhg, we establish a genetic toolbox for its engineering. We also demonstrate its ability to rapidly produce ethanol, 2,3-butanediol, and lycopene from brown macroalgae sugar mixture with high productivities and yields. Collectively, Vibrio sp. dhg can be used as a platform for the efficient conversion of brown macroalgae sugars into diverse value-added biochemicals.

Date: 2019
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DOI: 10.1038/s41467-019-10371-1

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