Hypervirulent Listeria monocytogenes clones’ adaption to mammalian gut accounts for their association with dairy products

Mylène M. Maury, Hélène Bracq-Dieye, Lei Huang, Guillaume Vales, Morgane Lavina, Pierre Thouvenot, Olivier Disson, Alexandre Leclercq, Sylvain Brisse and Marc Lecuit ()
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Mylène M. Maury: Institut Pasteur
Hélène Bracq-Dieye: Institut Pasteur
Lei Huang: Institut Pasteur
Guillaume Vales: Institut Pasteur
Morgane Lavina: Institut Pasteur
Pierre Thouvenot: Institut Pasteur
Olivier Disson: Institut Pasteur
Alexandre Leclercq: Institut Pasteur
Sylvain Brisse: Institut Pasteur
Marc Lecuit: Institut Pasteur

Nature Communications, 2019, vol. 10, issue 1, 1-13

Abstract: Abstract Listeria monocytogenes (Lm) is a major human and animal foodborne pathogen. Here we show that hypervirulent Lm clones, particularly CC1, are strongly associated with dairy products, whereas hypovirulent clones, CC9 and CC121, are associated with meat products. Clone adaptation to distinct ecological niches and/or different food products contamination routes may account for this uneven distribution. Indeed, hypervirulent clones colonize better the intestinal lumen and invade more intestinal tissues than hypovirulent ones, reflecting their adaption to host environment. Conversely, hypovirulent clones are adapted to food processing environments, with a higher prevalence of stress resistance and benzalkonium chloride tolerance genes and a higher survival and biofilm formation capacity in presence of sub-lethal benzalkonium chloride concentrations. Lm virulence heterogeneity therefore reflects the diversity of the ecological niches in which it evolves. These results also have important public health implications and may help in reducing food contamination and improving food consumption recommendations to at-risk populations.

Date: 2019
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DOI: 10.1038/s41467-019-10380-0

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