Supramolecular peptide constructed by molecular Lego allowing programmable self-assembly for photodynamic therapy

Huangtianzhi Zhu, Huanhuan Wang, Bingbing Shi, Liqing Shangguan, Weijun Tong, Guocan Yu (), Zhengwei Mao () and Feihe Huang ()
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Huangtianzhi Zhu: Zhejiang University
Huanhuan Wang: Zhejiang University
Bingbing Shi: Zhejiang University
Liqing Shangguan: Zhejiang University
Weijun Tong: Zhejiang University
Guocan Yu: Zhejiang University
Zhengwei Mao: Zhejiang University
Feihe Huang: Zhejiang University

Nature Communications, 2019, vol. 10, issue 1, 1-10

Abstract: Abstract Peptide self-assemblies with multiple nanostructures have great potentials in functional biomaterials, and yet the tedious and costly covalent peptide modification and the lack of facile controllability on self-assembly morphology retard the peptide-related exploration. Here we report a simple approach to fabricate a supramolecular peptide that shows programmable self-assembly with multiple morphologies and application in photodynamic therapy. Pillar[5]arene-based host−guest recognition is used to construct a supramolecular peptide, which simplify the peptide modification and promote the controllability of the self-assembly behavior. Due to the ERGDS sequences on the exterior surfaces and hydrophobic cores of self-assemblies, the nanoparticles formed from the supramolecular peptide are suitable vehicles to encapsulate a photosensitizer for photodynamic therapy. In vitro and in vivo studies demonstrate that the inherent targeting capability and supramolecular strategy greatly boost its photodynamic therapeutic efficiency. This supramolecular peptide holds promising potentials in precise cancer therapy and perspectives for the peptide modification.

Date: 2019
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DOI: 10.1038/s41467-019-10385-9

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