A shape-memory and spiral light-emitting device for precise multisite stimulation of nerve bundles

Hao Zheng, Zhitao Zhang, Su Jiang, Biao Yan, Xiang Shi, Yuanting Xie, Xu Huang, Zeyang Yu, Huizhu Liu, Shijun Weng, Arto Nurmikko, Yuqiu Zhang, Huisheng Peng (), Wendong Xu () and Jiayi Zhang ()
Additional contact information
Hao Zheng: Fudan University
Zhitao Zhang: Fudan University
Su Jiang: Fudan University
Biao Yan: Fudan University
Xiang Shi: Fudan University
Yuanting Xie: Fudan University
Xu Huang: Fudan University
Zeyang Yu: School of Engineering, Brown University
Huizhu Liu: Fudan University
Shijun Weng: Fudan University
Arto Nurmikko: School of Engineering, Brown University
Yuqiu Zhang: Fudan University
Huisheng Peng: Fudan University
Wendong Xu: Fudan University
Jiayi Zhang: Fudan University

Nature Communications, 2019, vol. 10, issue 1, 1-14

Abstract: Abstract We previously demonstrated that for long-term spastic limb paralysis, transferring the seventh cervical nerve (C7) from the nonparalyzed side to the paralyzed side results in increase of 17.7 in Fugl-Meyer score. One strategy for further improvement in voluntary arm movement is selective activation of five target muscles innervated by C7 during recovery process. In this study, we develop an implantable multisite optogenetic stimulation device (MOSD) based on shape-memory polymer. Two-site stimulation of sciatic nerve bundles by MOSD induces precise extension or flexion movements of the ankle joint, while eight-site stimulation of C7 nerve bundles induce selective limb movement. Long-term implant of MOSD to mice with severed and anastomosed C7 nerve is proven to be both safe and effective. Our work opens up the possibility for multisite nerve bundle stimulation to induce highly-selective activations of limb muscles, which could inspire further applications in neurosurgery and neuroscience research.

Date: 2019
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DOI: 10.1038/s41467-019-10418-3

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