Induction of memory-like dendritic cell responses in vivo

Camaron R. Hole, Chrissy M. Leopold Wager, Natalia Castro-Lopez, Althea Campuzano, Hong Cai, Karen L. Wozniak, Yufeng Wang and Floyd L. Wormley ()
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Camaron R. Hole: The University of Texas at San Antonio
Chrissy M. Leopold Wager: The University of Texas at San Antonio
Natalia Castro-Lopez: The University of Texas at San Antonio
Althea Campuzano: The University of Texas at San Antonio
Hong Cai: The University of Texas at San Antonio
Karen L. Wozniak: The University of Texas at San Antonio
Yufeng Wang: The University of Texas at San Antonio
Floyd L. Wormley: The University of Texas at San Antonio

Nature Communications, 2019, vol. 10, issue 1, 1-13

Abstract: Abstract Dendritic cells (DCs), a vital component of the innate immune system, are considered to lack antigen specificity and be devoid of immunological memory. Strategies that can induce memory-like responses from innate cells can be utilized to elicit protective immunity in immune deficient persons. Here we utilize an experimental immunization strategy to modulate DC inflammatory and memory-like responses against an opportunistic fungal pathogen that causes significant disease in immunocompromised individuals. Our results show that DCs isolated from protectively immunized mice exhibit enhanced transcriptional activation of interferon and immune signaling pathways. We also show long-term memory-like cytokine responses upon subsequent challenge with the fungal pathogen that are abrogated with inhibitors of specific histone modifications. Altogether, our study demonstrates that immunization strategies can be designed to elicit memory-like DC responses against infectious disease.

Date: 2019
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DOI: 10.1038/s41467-019-10486-5

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