Neuronal cell-subtype specificity of neural synchronization in mouse primary visual cortex

Ulf Knoblich, Lawrence Huang, Hongkui Zeng and Lu Li ()
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Ulf Knoblich: Allen Institute for Brain Science
Lawrence Huang: Allen Institute for Brain Science
Hongkui Zeng: Allen Institute for Brain Science
Lu Li: Sun Yat-sen Memorial Hospital, Sun Yat-sen University

Nature Communications, 2019, vol. 10, issue 1, 1-13

Abstract: Abstract Spatiotemporally synchronised neuronal activity is central to sensation, motion and cognition. Brain circuits consist of dynamically interconnected neuronal cell-types, thus elucidating how neuron types synergise within the network is key to understand the neuronal orchestra. Here we show that in neocortex neuron-network coupling is neuronal cell-subtype specific. Employing in vivo two-photon (2-p) Calcium (Ca) imaging and 2-p targeted whole-cell recordings, we cell-type specifically investigated the coupling profiles of genetically defined neuron populations in superficial layers (L) of mouse primary visual cortex (V1). Our data reveal novel subtlety of neuron-network coupling in inhibitory interneurons (INs). Parvalbumin (PV)- and Vasoactive intestinal peptide (VIP)-expressing INs exhibit skewed distributions towards strong network-coupling; in Somatostatin (SST)-expressing INs, however, two physiological subpopulations are identified with distinct neuron-network coupling profiles, providing direct evidence for subtype specificity. Our results thus add novel functional granularity to neuronal cell-typing, and provided insights critical to simplifying/understanding neural dynamics.

Date: 2019
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DOI: 10.1038/s41467-019-10498-1

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