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Microstructure arrays of DNA using topographic control

Yun Jeong Cha, Soon Mo Park, Ra You, Hyoungsoo Kim and Dong Ki Yoon ()
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Yun Jeong Cha: Korea Advanced Institute of Science and Technology
Soon Mo Park: Korea Advanced Institute of Science and Technology
Ra You: Korea Advanced Institute of Science and Technology
Hyoungsoo Kim: Korea Advanced Institute of Science and Technology (KAIST)
Dong Ki Yoon: Korea Advanced Institute of Science and Technology

Nature Communications, 2019, vol. 10, issue 1, 1-8

Abstract: Abstract DNA is a common biomaterial in nature as well as a good building block for producing useful structures, due to its fine feature size and liquid crystalline phase. Here, we demonstrate that a combination of shear-induced flow and microposts can be used to create various kinds of interesting microstructure DNA arrays. Our facile method provides a platform for forming multi-scale hierarchical orientations of soft- and biomaterials, using a process of simple shearing and controlled evaporation on a patterned substrate. This approach enables potential patterning applications using DNA or other anisotropic biomaterials based on their unique structural characteristics.

Date: 2019
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DOI: 10.1038/s41467-019-10540-2

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