Variation of a major facilitator superfamily gene contributes to differential cadmium accumulation between rice subspecies

Huili Yan, Wenxiu Xu, Jianyin Xie, Yiwei Gao, Lulu Wu, Liang Sun, Lu Feng, Xu Chen, Tian Zhang, Changhua Dai, Ting Li, Xiuni Lin, Zhanying Zhang, Xueqiang Wang, Fengmei Li, Xiaoyang Zhu, Jinjie Li, Zichao Li, Caiyan Chen, Mi Ma, Hongliang Zhang () and Zhenyan He ()
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Huili Yan: Institute of Botany, Chinese Academy of Sciences
Wenxiu Xu: Institute of Botany, Chinese Academy of Sciences
Jianyin Xie: China Agricultural University
Yiwei Gao: Beijing Forestry University
Lulu Wu: Institute of Botany, Chinese Academy of Sciences
Liang Sun: Institute of Subtropical Agriculture, Chinese Academy of Sciences
Lu Feng: Institute of Botany, Chinese Academy of Sciences
Xu Chen: Institute of Botany, Chinese Academy of Sciences
Tian Zhang: Institute of Botany, Chinese Academy of Sciences
Changhua Dai: Institute of Botany, Chinese Academy of Sciences
Ting Li: Institute of Botany, Chinese Academy of Sciences
Xiuni Lin: Beijing Forestry University
Zhanying Zhang: China Agricultural University
Xueqiang Wang: China Agricultural University
Fengmei Li: China Agricultural University
Xiaoyang Zhu: China Agricultural University
Jinjie Li: China Agricultural University
Zichao Li: China Agricultural University
Caiyan Chen: Institute of Subtropical Agriculture, Chinese Academy of Sciences
Mi Ma: Institute of Botany, Chinese Academy of Sciences
Hongliang Zhang: China Agricultural University
Zhenyan He: Institute of Botany, Chinese Academy of Sciences

Nature Communications, 2019, vol. 10, issue 1, 1-12

Abstract: Abstract Cadmium (Cd) accumulation in rice grain poses a serious threat to human health. While several transport systems have been reported, the complexity of rice Cd transport and accumulation indicates the necessity of identifying additional genes, especially those that are responsible for Cd accumulation divergence between indica and japonica rice subspecies. Here, we show that a gene, OsCd1, belonging to the major facilitator superfamily is involved in root Cd uptake and contributes to grain accumulation in rice. Natural variation in OsCd1 with a missense mutation Val449Asp is responsible for the divergence of rice grain Cd accumulation between indica and japonica. Near-isogenic line tests confirm that the indica variety carrying the japonica allele OsCd1V449 can reduce the grain Cd accumulation. Thus, the japonica allele OsCd1V449 may be useful for reducing grain Cd accumulation of indica rice cultivars through breeding.

Date: 2019
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DOI: 10.1038/s41467-019-10544-y

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