Layer-specific integration of locomotion and sensory information in mouse barrel cortex

Aslı Ayaz (), Andreas Stäuble, Morio Hamada, Marie-Angela Wulf, Aman B. Saleem and Fritjof Helmchen
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Aslı Ayaz: University of Zurich
Andreas Stäuble: University of Zurich
Morio Hamada: University of Zurich
Marie-Angela Wulf: University of Zurich and ETH Zurich
Aman B. Saleem: University College London
Fritjof Helmchen: University of Zurich

Nature Communications, 2019, vol. 10, issue 1, 1-14

Abstract: Abstract During navigation, rodents continually sample the environment with their whiskers. How locomotion modulates neuronal activity in somatosensory cortex, and how it is integrated with whisker-touch remains unclear. Here, we compared neuronal activity in layer 2/3 (L2/3) and L5 of barrel cortex using calcium imaging in mice running in a tactile virtual reality. Both layers increase their activity during running and concomitant whisking, in the absence of touch. Fewer neurons are modulated by whisking alone. Whereas L5 neurons respond transiently to wall-touch during running, L2/3 neurons show sustained activity. Consistently, neurons encoding running-with-touch are more abundant in L2/3 and they encode the run-speed better during touch. Few neurons across layers were also sensitive to abrupt perturbations of tactile flow during running. In summary, locomotion significantly enhances barrel cortex activity across layers with L5 neurons mainly reporting changes in touch conditions and L2/3 neurons continually integrating tactile stimuli with running.

Date: 2019
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DOI: 10.1038/s41467-019-10564-8

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