Regulation of CAR T cell-mediated cytokine release syndrome-like toxicity using low molecular weight adapters

Yong Gu Lee, Haiyan Chu, Yingjuan Lu, Christopher P. Leamon, Madduri Srinivasarao, Karson S. Putt and Philip S. Low ()
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Yong Gu Lee: Purdue University
Haiyan Chu: Endocyte Inc.
Yingjuan Lu: Endocyte Inc.
Christopher P. Leamon: Endocyte Inc.
Madduri Srinivasarao: Purdue University
Karson S. Putt: Purdue University
Philip S. Low: Purdue University

Nature Communications, 2019, vol. 10, issue 1, 1-11

Abstract: Abstract Although chimeric antigen receptor (CAR) T cell therapies have demonstrated considerable success in treating hematologic malignancies, they have simultaneously been plagued by a cytokine release syndrome (CRS) that can harm or even kill the cancer patient. We describe a CAR T cell strategy in which CAR T cell activation and cancer cell killing can be sensitively regulated by adjusting the dose of a low molecular weight adapter that must bridge between the CAR T cell and cancer cell to initiate tumor eradication. By controlling the concentration and dosing schedule of adapter administration, we document two methods that can rapidly terminate (

Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-10565-7

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DOI: 10.1038/s41467-019-10565-7

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