Mechanistic basis of L-lactate transport in the SLC16 solute carrier family

Patrick D. Bosshart, David Kalbermatter, Sara Bonetti and Dimitrios Fotiadis ()
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Patrick D. Bosshart: University of Bern
David Kalbermatter: University of Bern
Sara Bonetti: University of Bern
Dimitrios Fotiadis: University of Bern

Nature Communications, 2019, vol. 10, issue 1, 1-11

Abstract: Abstract In human and other mammalian cells, transport of L-lactate across plasma membranes is mainly catalyzed by monocarboxylate transporters (MCTs) of the SLC16 solute carrier family. MCTs play an important role in cancer metabolism and are promising targets for tumor treatment. Here, we report the crystal structures of an SLC16 family homologue with two different bound ligands at 2.54 and 2.69 Å resolution. The structures show the transporter in the pharmacologically relevant outward-open conformation. Structural information together with a detailed structure-based analysis of the transport function provide important insights into the molecular working mechanisms of ligand binding and L-lactate transport.

Date: 2019
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DOI: 10.1038/s41467-019-10566-6

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