Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data

Dmitry Shungin, Simon Haworth (), Kimon Divaris, Cary S. Agler, Yoichiro Kamatani, Myoung Keun Lee, Kelsey Grinde, George Hindy, Viivi Alaraudanjoki, Paula Pesonen, Alexander Teumer, Birte Holtfreter, Saori Sakaue, Jun Hirata, Yau-Hua Yu, Paul M. Ridker, Franco Giulianini, Daniel I. Chasman, Patrik K. E. Magnusson, Takeaki Sudo, Yukinori Okada, Uwe Völker, Thomas Kocher, Vuokko Anttonen, Marja-Liisa Laitala, Marju Orho-Melander, Tamar Sofer, John R. Shaffer, Alexandre Vieira, Mary L. Marazita, Michiaki Kubo, Yasushi Furuichi, Kari E. North, Steve Offenbacher, Erik Ingelsson, Paul W. Franks, Nicholas J. Timpson and Ingegerd Johansson
Additional contact information
Dmitry Shungin: Umeå University
Simon Haworth: Medical Research Council Integrative Epidemiology Unit, Bristol Medical School
Kimon Divaris: University of North Carolina
Cary S. Agler: University of North Carolina
Yoichiro Kamatani: RIKEN Center for Integrative Medical Sciences
Myoung Keun Lee: University of Pittsburgh
Kelsey Grinde: University of Washington
George Hindy: Lund University
Viivi Alaraudanjoki: Research Unit of Oral Health Sciences University of Oulu
Paula Pesonen: Faculty of Medicine, University of Oulu
Alexander Teumer: University Medicine Greifswald
Birte Holtfreter: and Preventive and Pediatric Dentistry University Medicine Greifswald
Saori Sakaue: Osaka University Graduate School of Medicine
Jun Hirata: Osaka University Graduate School of Medicine
Yau-Hua Yu: Brigham and Women’s Hospital
Paul M. Ridker: Brigham and Women’s Hospital
Franco Giulianini: Brigham and Women’s Hospital
Daniel I. Chasman: Brigham and Women’s Hospital
Patrik K. E. Magnusson: Karolinska Instituet
Takeaki Sudo: Graduate School of Medical and Dental Science of Tokyo Medical and Dental University
Yukinori Okada: Osaka University Graduate School of Medicine
Uwe Völker: University Medicine Greifswald
Thomas Kocher: and Preventive and Pediatric Dentistry University Medicine Greifswald
Vuokko Anttonen: Research Unit of Oral Health Sciences University of Oulu
Marja-Liisa Laitala: Research Unit of Oral Health Sciences University of Oulu
Marju Orho-Melander: Lund University
Tamar Sofer: Harvard Medical School
John R. Shaffer: University of Pittsburgh
Alexandre Vieira: University of Pittsburgh
Mary L. Marazita: University of Pittsburgh
Michiaki Kubo: RIKEN Center for Integrative Medical Sciences
Yasushi Furuichi: Health Sciences University of Hokkaido
Kari E. North: University of North Carolina
Steve Offenbacher: University of North Carolina
Erik Ingelsson: Stanford University School of Medicine
Paul W. Franks: Genetic and Molecular Epidemiology Unit, Lund University
Nicholas J. Timpson: Medical Research Council Integrative Epidemiology Unit, Bristol Medical School
Ingegerd Johansson: Umeå University

Nature Communications, 2019, vol. 10, issue 1, 1-13

Abstract: Abstract Dental caries and periodontitis account for a vast burden of morbidity and healthcare spending, yet their genetic basis remains largely uncharacterized. Here, we identify self-reported dental disease proxies which have similar underlying genetic contributions to clinical disease measures and then combine these in a genome-wide association study meta-analysis, identifying 47 novel and conditionally-independent risk loci for dental caries. We show that the heritability of dental caries is enriched for conserved genomic regions and partially overlapping with a range of complex traits including smoking, education, personality traits and metabolic measures. Using cardio-metabolic traits as an example in Mendelian randomization analysis, we estimate causal relationships and provide evidence suggesting that the processes contributing to dental caries may have undesirable downstream effects on health.

Date: 2019
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DOI: 10.1038/s41467-019-10630-1

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